William Frederick Stenson, MD
Dr. Nicholas V. Costrini Professor of Gastroenterology & Inflammatory Bowel Disease, Division of Gastroenterology
Inflammatory Bowel Disease
Areas of Clinical Interest
Washington University School of Medicine, Division of Gastroenterology
660 South Euclid Avenue, Campus Box 8124
Gastroenterology, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, celiac disease
B.S.: Providence College, Providence, Rhode Island, 1967
Medical Degree: Washington University School of Medicine, St Louis, Missouri, 1971
Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis, Missouri, 1976
Fellowship: Gastroenterology, Washington University School of Medicine, St Louis, Missouri, 1978
Selected or Recent Journal Articles
Sundaresan, S, Shahid, R., Riehl, T.E., Chandra, R., Nassir, F., Stenson, W.F., Liddle, R.A., and Abumrad, N.A. CD36- dependent signaling mediates fatty acid induced gut release of secretin and cholecystokinin. FASEB . Journal, in press.
Riehl TE, Ee,X, Stenson WF. Hyaluronic Acid Regulates Normal Intestinal and Colonic Growth in Mice. Am J Physiol (Gastrointest Liver Physiol). 2012; 303(3):G377-88
Ciorba M, Riehl TE, Rao S, Moon C, Ee X, Nava G, Walker M, Marinshaw J, Stappenbeck T, Stenson WF. Lactobacillus probiotic protects intestinal epithelium from radiation injury in TLR-2/cyclooxygenase-2 dependent manner. GUT 2012;61(6):829-838.
Riehl TE, Foster L, Stenson WF. Hyaluronic Acid is Radioprotective in the Intestine through a TLR-4 and COX-2 Mediated Mechanism. Am J Physiol . 2011; 302:G309-G316.
Gupta N, Thaker A, Kanuri N, Riehl T, Rowley C, Stenson WF, Ciorba MA. Serum Analysis of Tryptophan Catabolism Pathway: Correlation with Crohn’s Disease Activity. Inflamm Bowel Dis. 2011 Aug 5.
Riehl TE, He L, Zheng L, Greco S, Tollefsen D, Stenson WF. COX-1+/-COX-2-/- genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1. Journal of Thrombosis Haemostasis.9:1-10;2011
Ciorba MA, Bettonville EE, McDonald K, Metz R, Prendergast C, Newberry RD, Stenson, WF. Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental Colitis. J. Immunol 184;3907-3916:2010.
Walker MR, Brown SL, Riehl TE, Stenson WF, Stappenbeck TS. Growth factor regulation of prostaglandin-endoperoxide synthase 2 (PTGS2) expression in colonic mesenchymal stem cells. J Biol Chem. 285(7);5026-5039:2010
Katona BW, Anant S, Stenson WF. Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. Journal of Biological Chemistry 284(5):3354-64,2009
Ciorba M, Stenson WF. Probiotic therapy in radiation-induced intestinal injury and repair. Ann NY Acad Sci.1165:190-4,2009
Zheng L, Riehl T, Stenson WF. Regulation of Colonic Epithelial Repair in Mice by Toll-like Receptors and Hyaluronic Acid. Gastroenterology. 137(6);2041-51:2009.
Alford SK, Longmore GD, Stenson WF, Kemper C. CD46-induced immunomodulatory CD4+T cells express the adhesion molecule and chemokines receptor pattern of intestinal T cells. Journal of Immunology. 15;181(4):2544-55: 2008
Katona BW, Rath NP, Anant S, Stenson WF, Covey DF. Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines. Journal of Organic Chemistry. 72(24):9298-307;2007
Brown SL, Riehl TE, Walker MR, Geske MJ, Doherty JM, Stenson WF, Stappenbeck TS. Myd88- dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. In press. J. Clin. Invest,117:258-69;2007
James DG, Stone CD, Wang HL, Stenson WF. Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease. Inflammatory Bowel Diseases. 12:573-80, 2006.