Pediatrics

 

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Home > Physicians Directory > Pediatrics

Michael R. DeBaun, MD, MPH FAAP

Specialty Areas
Pediatric Hematology
Pediatrics
Pediatric Oncology

Areas of Clinical Interest
Sickle cell disease, asthma and pulmonary disease in children with sickle cell anemia


Areas of Research Interest
Hematology: understanding of the etiology, and management of cerebrovascular injury in children with sickle cell disease.  Also,  the epidemiology, clinical significance and genetic basis for asthma in children with sickle cell anemia

Oncology: the epidemiology, optimal management and molecular basis for an overgrowth syndrome associated with cancer in children, Beckwith-Wiedemann Syndrome (BWS).

Silent Infarct Transfusion (SIT) Trial - Website

Sleep and Asthma Cohort (SAC) Study - Website


Major or Recent Publications/Awards
Honors, Distinctions and Awards

Listed in Best Doctors in America, 2003 - 2009 (Best Doctors, Inc)

Listed in America's Top Doctors, Castle Connolly, 2005-2009

2009 Distinguished Faculty Award - Daniel P. Schuster Award for Distinguished Work in Clinical and Translational Science

2009 Distinguished Faculty Award, Founders Day, Washington University School of MedicineDoris Duke Clinical Scientist Development Award

2008 National Medical Association Scroll of Merit Award

2008 Clinical Teacher of the Year Award, Washington University School of Medicine, Department of Pediatrics

2006 American Society for Clinical Investigation, Inductee

2004 Advocacy Award, American Society of Hematology

2003 Clinical Teacher of the Year Award, Washington University School of Medicine, Department of Pediatrics

2002 Humanism in Medicine Award, Washington University School of Medicine

1999-2004 Doris Duke Clinical Scientist Development Award

1996-2000 Robert Wood Johnson Minority Faculty Development Award, 1996-2000

1992-1996 United States Public Health Service Epidemiology Fellowship, Genetic Epidemiology Branch, National Cancer Institute

Selected Journal Publications

Sickle Cell Disease

Field JJ, Knight-Perry JE, DeBaun MR. Acute pain in children and adults with sickle cell disease: management in the absence of evidence-based guidelines. Curr Opin Hematol 2009;16(3):173-8.

Field JJ, Strunk RC, Knight-Perry JE, Blinder MA, Townsend RR, DeBaun MR. Urinary cysteinyl leukiotriene E4 significantly increases during pain in children and adults with sickle cell disease. Am J Hematol 2009;84(4):231-3.

Knight-Perry JE, DeBaun MR, Strunk RC, Field JJ. Leukotriene pathway in sickle cell disease: a potential target for directed therapy. Expert Rev Hematol 2009;2(1):57-60.

Frei-Jones MJ, Field JJ, DeBaun MR. Multi-modal intervention reduces 30-day hospital readmission rate in children with sickle cell disease. Pediatr Blood Cancer 2009;53(3): 401-5. Epub ahead of print May 6.

Phillips KL, An P, Boyd JH, Strunk RC, Casella JF, Barton BA, DeBaun MR. Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma. Am J Hum Biol 2008; 20(2):149-53.

King AA, Noetzel M, White DA, McKinstry RC, DeBaun MR. Blood transfusion therapy is feasible in a clinical trial setting in children with sickle cell disease and silent cerebral infarcts. Pediatr Blood Cancer 2008; 50(3); 599-602.

King AA, White DA, McKinstry RC, Noetzel M, DeBaun MR. A pilot randomized education rehabilitation trial is feasible in sickle cell and strokes. Neurology 2007;68:2008-2011.

Boyd JH, Macklin EA, Strunk RA, DeBaun MR. Asthma is associated with increased mortality in individuals with sickle cell anemia. Haematologica 2007;92(8):1115-8.

Jennings JE, Ramkumar T, Mao J, Boyd J, Castro M, Field, J, Strunk, RC, DeBaun MR. Elevated Urinary Leukotriene E4 Levels are Associated with Hospitalization for Pain in Children with Sickle Cell Am J Hematol 2008 Aug;83(8):640-3.

Frei-Jones MJ, DeBaun MR. Guidelines for the Treatment of Sickle Cell Disease-Related Pain in Hospitalized Children. J Pain Management 2008;1(2):95-128.

Goers T, Panepinto J, Blinder M, DeBaun M, Folgia R, Field J. Laparoscopic Versus Open Abdominal Surgery in Children with Sickle Cell Disease is Associated with a Shorter Hospital Stay. Pediatric Blood & Cancer 2008; 50(3): 603-6.

Strunk RC, Brown MS, Boyd JH, Bates P, Field JJ, DeBaun MR. Methacholine challenge in children with sickle cell disease: a case series. Pediatr Pulmonol 2008; 54(9):924-929.

Hulbert ML, Scothorn DJ, Panepinto JA, Scott JP, Buchanan GR, Shurney W, Sarniak I, Fallon R, Chu JY, Pegelow C, Wang W, Casella J, Resar L, Berman B, Adamkiewicz T, Hsu LL, Smith-Whitley K, Mahoney D, Scott JP, Woods G, Watanabe M, DeBaun MR. Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia. J Pediatrics 2006;149(5):710-2.

Isaak EJ, Lechien B, Lindsey T, DeBaun MR. The Charles Drew Program in Missouri: a description of a partnership among a blood center and several hospitals to address the care of patients with sickle cell disease. Immunohematol 2006;22(3):112-16.

Cancer Predisposition Syndromes

Martin RA, Grange DK, Zehnbauer B, DeBaun MR: LIT1 and H19 methylation defects in isolated hemihyperplasia. Am J Human Genet, 2005;13;134(2):129-131.

Niemitz EL, Feinberg, AP, Brandenburg SA, Grundy PE, DeBaun MR: Children with Isolated Hemihypertrophy and Beckwith Wiedemann Sydrome have Different Constitutional Eipgenotypes Associated with Wilms Tumor. Am J Human Genet, 2005;77(5):887-91.

DeBaun MR, Niemitz EL, Feinberg AP: Association of in vitro fertilization with Beckwith-Wiedemann Syndrome and epigenetic alterations of LIT1 and H19. Am J Human Genet 2003; 72(1):156-160.

Clericuzio CL, Chen E, McNeil DE, O'Connor T, Zackai EH, Medne L, Tomlinson G, DeBaun MR: Serum alpha-fetoprotein screening for hepatoblastoma in children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia. J Pediatr 2003; 143:270-272.

Epidemiology and Public Health

DeBaun MR, Gorelick PB, Som S. Strategies for recruiting and retaining minorities. Front Neurol Neuroci 2009;25:118-20.

Price CL, Johnson MT, Lindsay T, Dalton D, Watkins AR, DeBaun MR. The sickle cell Sabbath: a community program increases first-time blood donors in the African-American faith community. Transfusion 2009; Mar. 49(3):519-23. Epub 2008 Nov 25. Erratum in Transfusion 2009; Mar. 49(3):610.

Kistka ZA, Palomar L, Boslaugh SE, DeBaun MR, DeFranco EA. Risk for postterm delivery after previous postterm delivery. Am J Obstet Gynecol 2007; 196(3): 241.el – 241.e6.

Kistka ZA, Palomar L, Lee KA, Boslaugh SE, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol 2007; 196(2):131.e1 – 131.e6.