Alan Pestronk, MD
Current Position
Professor, Neurology
Section Chief, Neuromuscular Diseases
Professor, Pathology
Director, Neuromuscular Clinical Laboratory
Specialty Areas
Neurology - Adult
Myasthenia Gravis
Nerve Disorders
Muscle Disorders
Neuromuscular Disease
Muscular Dystrophy
ALS - Lou Gehrig's Disease
Mailing Address
|
Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis,
MO
63110
|
Areas of Clinical Interest
Clinical neurology, neuromuscular disease, neuroimmunology, glycolipids, proteoglycans, aging and the nervous system, history of neurology, myopathy, neuropathy, weakness, myasthenia, muscle, nerve, numbness, sensory loss, pain, fatigue, muscular dystrophy, neuro muscular.
More Information on the Neuromuscular Disease Center
Board Certification
Neurology
--
Certified
Medical Education
B.A.: Princeton University, Princeton, New Jersey
, 1966
Medical Degree: Johns Hopkins School of Medicine, Baltimore, Maryland
, 1970
Residency: Neurology, Johns Hopkins Hospital, Baltimore, Maryland
, 1973
Chief Residency: Neurology, Johns Hopkins Hospital, Baltimore, Maryland
, 1974
Fellowship: Neuromuscular Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland
, 1977
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital
Major or Recent Publications/Awards
Awards
Listed in Best Doctors in America, 2002 - 2009 (Best Doctors, Inc)
Listed in America's Top Doctors, Castle Connolly Medical Ltd, 2005 - 2008
Outstanding Healthcare Professional, Greater St. Louis ALS Association 1999
Outstanding Physician, St. Louis Muscular Dystrophy Association 1998
Sven Eliasson Award for Outstanding Teaching, Washington University Department of Neurology 1992
Frank R. Ford Award for Outstanding Teaching, Johns Hopkins Department of Neurology 1988
Lawrence C. McHenry Award for Excellence in the History of Neurology 1987
Resident Teaching Award, Johns Hopkins Department of Neurology 1987
Medical Leader-Neurology in China (Beijing, Tiangin, Shanghai) 1983
Editorial Responsibilities
Journal of Neuroimmunology
Muscle & Nerve
Journal Articles
Forman MS, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman
DA, Jhaveri BS, Karlawish JH, Pestronk A, Smith TW, Tu PH, Watts GD,
Markesbery WR, Smith CD, Kimonis VE. Novel ubiquitin neuropathology in
frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol 2006; Jun;65(6):571-81.PMID: 16783167 [PubMed - indexed for MEDLINE]
Weihl CC, Connolly AM, Pestronk A. Valproate may improve strength
and function in patients with type III/IV spinal muscle atrophy. Neurology 2006; Aug 8;67(3):500-1. Epub 2006 Jun 14.
PMID: 16775228 [PubMed - in process]
Sampson JB, Chin SS, Clayton FC, Pestronk A, Swoboda KJ, Flanigan
KM. An unusual pathologic feature associated with dermatomyositis. Neuromuscul Disord 2006; Jun;16(6):391-3. Epub 2006 May 11.
PMID: 16697198 [PubMed - in process]
Pestronk A, Kos K, Lopate G, Al-Lozi MT. Brachio-cervical inflammatory myopathies: clinical, immune, and myopathologic features. Arthritis Rheum 2006 May;54(5):1687-96.
PMID: 16646041 [PubMed - indexed for MEDLINE]
Strom RG, Derdeyn CP, Moran CJ, Cross DT, Esper GJ, Mazumdar A,
Al-Lozi M, Lopate G, Pestronk A. Frequency of spinal arteriovenous
malformations in patients with unexplained myelopathy. Neurology 2006; Mar 28;66(6):928-31.
PMID: 16567716 [PubMed - indexed for MEDLINE]
Lopate G, Pestronk A, Al-Lozi M, Lynch T, Florence J, Miller T,
Levine T, Rampy T, Beson B, Ramneantu I. Peripheral neuropathy in an
outpatient cohort of patients with Sjogren's syndrome. Muscle Nerve 2006; May;33(5):672-6.
PMID: 16453296 [PubMed - indexed for MEDLINE]
Levine T, Pestronk A, Florence J, Al-Lozi MT, Lopate G, Miller T,
Ramneantu I, Waheed W, Stambuk M, Stone MJ, Choksi R. Peripheral
neuropathies in Waldenstrom's macroglobulinaemia. J Neurol Neurosurg Psychiatry 2006 Feb;77(2):224-8.
PMID: 16421127 [PubMed - indexed for MEDLINE]
Weihl CC, Dalal S, Pestronk A, Hanson PI. Inclusion body
myopathy-associated mutations in p97/VCP impair endoplasmic
reticulum-associated degradation. Hum Mol Genet. 2006 Jan 15;15(2):189-99. Epub 2005 Dec 1.
PMID: 16321991 [PubMed - indexed for MEDLINE]
Ferrante KL, Shefner J, Zhang H, Betensky R, O'Brien M, Yu H,
Fantasia M, Taft J, Beal MF, Traynor B, Newhall K, Donofrio P, Caress
J, Ashburn C, Freiberg B, O'Neill C, Paladenech C, Walker T, Pestronk
A, Abrams B, Florence J, Renna R, Schierbecker J, Malkus B, Cudkowicz
M. Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS. Neurology. 2005 Dec 13;65(11):1834-6.PMID: 16344537 [PubMed - indexed for MEDLINE]
Escolar DM, Buyse G, Henricson E, Leshner R, Florence J, Mayhew J,
Tesi-Rocha C, Gorni K, Pasquali L, Patel KM, McCarter R, Huang J,
Mayhew T, Bertorini T, Carlo J, Connolly AM, Clemens PR, Goemans N,
Iannaccone ST, Igarashi M, Nevo Y, Pestronk A, Subramony SH,
Vedanarayanan VV, Wessel H; CINRG Group. CINRG randomized controlled
trial of creatine and glutamine in Duchenne muscular dystrophy. Ann Neurol 2005 Jul;58(1):151-5.
PMID: 15984021 [PubMed - indexed for MEDLINE]
Lopate G, Pestronk A, Evans S, Li L, Clifford D. Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy. Neurology 2005 May 10;64(9):1632-4.
PMID: 15883332 [PubMed - indexed for MEDLINE]
Lopate G, Pestronk A, Al-Lozi M. Treatment of chronic inflammatory
demyelinating polyneuropathy with high-dose intermittent intravenous
methylprednisolone.
Arch Neurol. 2005 Feb;62(2):249-54.
PMID: 15710853 [PubMed - indexed for MEDLINE]
Pestronk A. Inflammatory and immune myopathies: concepts in diagnosis and treatment. J Child Neurol 2002; Mar;17(3):205
Mozaffar T, Pestronk A. Myopathy with anti-Jo-1 antibodies: Pathology in perimysium and neighbouring muscle fibres. J Neurol Neurosurg Psychiatry 2000; 68:472-478
Calhoun RF, Ritter JH, Guthrie TJ, Pestronk A, Meyers BF, Patterson GA, Pohl MS, Cooper JD. Results of transcervical thymectomy for myasthenia gravis in 100 consecutive patients. Annals of Surgery 1999; 230:555-561
Nevo Y, Al-Lozi M, Parsadanian AS, Elliott JL, Connolly AM, Pestronk A. Mutation analysis in Emery-Dreifuss muscular dystrophy. Pediatric Neurology 1999; 21:456-459
Patton BL, Connolly AM, Martin PT, Cunningham JM, Mehta S, Pestronk A, Miner JH, Sanes JR. Distribution of ten laminin chains in dystrophic and regenerating muscles. Neuromuscular Disorders 1999; 9:423-433
Levine TD, Pestronk A. IgM antobody-related polyneuropathies: Teatment
with B-cell depletion chemotherapy using rituximab. Neurology 1999;
52:1701-1704
Connolly AM, Chez MG, Pestronk A, Arnold ST, Mehta S, Deuel RK. Serum
autoantibodies to brain in Landau-Kleffner variant, autism and other
neurologic disorders. J Pediat 1999; 134:607-613
Pestronk A, Choksi R, Yee EC, Kornberg AJ, Lopate G, Trotter J. Serum
antibodies to heparan sulfate glycosaminoglycans in Guillain-Barre'
syndrome and other demyelinating polyneuropathies. J. Neuroimmunol
1998; 91:204-209
Levine T, Pestronk A. Inflammatory myopathy with cytochrome oxidase
negative muscle fibers: Methotrexate treatment. Muscle Nerve 1998;
12:1724-1728
Connolly AM, Pestronk A, Mehta S, Al-Lozi M. Autosomal recessive to prednisone. Muscle Nerve 1998; 21:1549-1553
Mozaffar T, Pestronk A. Clinical correlates of granulomas in muscle. J Neurol 1998; 245:519-524
Lopate G, Pestronk A, Yee W-C. N lines in a myopathy with myosin loss. Muscle Nerve 1998; 21:1216-1219
Al-Lozi MT, Hemelt VB, Pestronk A. Steroid-responsive myopathy with
deficient chondroitin sulfate C in skeletal muscle connective tissue.
Neurology 1998; 50:526-529
Stambler NL, Charatan M, Cedarbaum JM, ALS CNTF Study Group. Prognostic indicators of survival in ALS. Neurology 1998; 50:66-72
Levin MI, Mozaffar T, Al-Lozi MT, Pestronk A. Paraneoplastic
necrotizing myopathy: Clinical and pathological features. Neurology
1998; 50:764-767
Connolly AM, Pestronk A. Anti-tubulin autoantibodies in acquired
demyelinating polyneuropathies. J Infect Dis 1997; 176(Suppl2):S157-159
Al-Lozi MT, Pestronk A, Choksi R. A skeletal muscle-specific form of
decorin is a target for a serum IgM-protein in a patient with a
proximal myopathy. Neurology 1997; 49:1650-1654
Pestronk A, Choksi R. Multifocal motor neuropathy: Serum IgM anti-GM1
ganglioside antibodies in most patients detected using covalent linkage
of GM1 to ELISA plates. Neurology 1997; 49:1289-1292
Nevo Y, Pestronk A. Acute immune neuropathies: Serum antibodies to
Campylobacter jejuni, Helicobacter pylori, and GM1 ganglioside. J
Infect Dis 1997; 176(Suppl2):S154-156
For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Alan Pestronk